In 2005 Katherine Marie Heigl was cast in what would become her most high-profile role, as intern Dr. Isobel "Izzie" Stevens on Grey's Anatomy, an ABC medical drama. The show, originally introduced as a midseason replacement, has become a huge ratings success.
The same year, Katherine Marie Heigl landed the starring role of Karly Hert in the independent film Side Effects, about marketing and the pharmaceutical industry.
In late 2006,Katherine Marie Heigl was nominated for a Golden Globe award in the category, Best Supporting Actress in a Series, Mini-series, or Motion Picture Made for Television for Katherine Marie Heigl's work on Grey's. Also in 2006, she filmed Knocked Up, a comedy from writer/director Judd Apatow, starring opposite Seth Rogen.
Upon its June 2007 theatrical release, the film received largely positive reviews from critics, and proved to be a box office success.
